Which model predicts high-risk CAD?

The model (C statistic, 0.75) was a better predictor of high-risk CAD compared with both the Pooled Cohort Equation (PCE; C statistic, 0.70; χ 2 =18.18; P <0.0001) 21 and modified Diamond-Forrester risk score (mDFS), aimed at symptomatic chest pain patients (C statistic, 0.68; χ 2 =26.90; P <0.0001).

Do CAD genetic risk scores predict cardiovascular risk?

CAD genetic risk scores (GRSs) predict risk independently from clinical tools, like QRISK3. We assessed the added value of GRSs for a variety of cardiovascular traits (CV GRSs) for predicting CAD and MACE and tested their early-life screening potential by comparing against the CAD GRS only.

What does CAD stand for?

Figure 1. Flowchart indicating the number of individuals included in the study and the partition into training and test for coronary artery disease (CAD) and major adverse cardiovascular event (MACE) end points.

Is CAD genetic risk stratification a good idea?

Coronary artery disease (CAD) and major adverse cardiovascular events (MACE) are the leading causes of death in the general population, but risk stratification remains suboptimal. CAD genetic risk scores (GRSs) predict risk independently from clinical tools, like QRISK3.